- Title
- Outcomes of nodal metastatic cutaneous squamous cell carcinoma of the head and neck treated in a regional center
- Creator
- Schmidt, Campbell; Martin, Jarad M.; Khoo, Eric; Plank, Ashley; Grigg, Roger
- Relation
- Head & Neck: journal for the sciences and specialities of the head and neck Vol. 37, Issue 12, p. 1808-1815
- Publisher Link
- http://dx.doi.org/10.1002/hed.23843
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2015
- Description
- Background: Given its metastatic potential and high incidence, cutaneous squamous cell carcinoma of the head and neck (SCCHN) has significant morbidity and mortality. Methods: We conducted a retrospective review of prospectively collected data for 113 consecutive patients with nodal metastatic cutaneous SCCHN treated surgically with curative intent in a regional center. Survival curves were generated by the Kaplan–Meier method. Results: Five-year overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were 80%, 83%, and 75%, respectively. Twenty-six patients (23%) relapsed, with 92% of relapses occurring within 2 years of surgery. Immunosuppression (p = .008) and N classification (p = .043) predicted decreased DFS on univariate analysis. On multivariate analysis, only immunosuppression independently predicted DFS (p = .034). Conclusion: This study validates the current N classification system, supports the adverse effect of immunosuppression, and suggests that intense follow-up for 2 years postsurgery is warranted. Survival at this regional center is comparable to that achieved at metropolitan tertiary cancer centers.
- Subject
- carcinoma; squamous cell; head and neck neoplasms; lymphatic metastasis; survival analysis; rural health services
- Identifier
- http://hdl.handle.net/1959.13/1327641
- Identifier
- uon:25708
- Identifier
- ISSN:1043-3074
- Language
- eng
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